Puerto Rican by descent, Marisol Rodriguez grew up in the Phillipines, Texas and Florida because her father was in the Air Force. She started acting when she was living in Florida.

In 1987, Marisol graduated from the University of Southern California with a degree in drama. That same year, she made her television acting debut as Carmen Castillo on Santa Barbara. She had her original screentest for SB with A Martinez (Cruz).

Marisol's birthdate is October 10, 1965.